COVID-19 DIARY – ROLL OUT ROLL UP – PART XII

What is the Moderna COVID vaccine? Does it work, and is it safe?

May 13

Thursday Australia announced a deal to procure 25 million doses of the American Moderna vaccine with 10 million jabs hopefully by the end of year and then 25 million booster jabs next year to deal with variants.

As the federal govenrnemt looked to set-up production of MRNA vaccines in Australia Moderna’s CEO Stephane Bancel said in a statement, “We look forward to continuing discussions with Australia about establishing potential local manufacturing opportunities.

Adelaide plant BioCina who had bought a plant in Adelaide off Pfizer threw its hat into the ring as being able to produce MRNA vaccines like Moderna at its facility within 12 months.

We can have the ability to manufacture a hundred, a hundred and fifty million doses that would serve the region rather than just Australia so there is an export oppourtunity as well,” BioCina Chief Executive Ian Wisenberg said.

This followed deals with AstraZeneca, Pfizer and Novaxin and Moderna would still need to secure the Therapeutic Goods Administration.

If supplies from Pfizer were delayed maybe ones from Moderna, which had a cited efficacy rate of 94.1 per cent, might help with numbers..

We think there is no reason why you can’t mix and match vaccines. The trial data is not out yet. There’s some trials being done UK looking at AstraZeneca first done and Pfizer or Moderna second dose.” Department of Health Secretary Professor Brendan Murphy said looking ahead to the future.

The Univesity of South Australia was also developing a vaccine in partnership with Biotech Company Semetis had also received three million dollars from the Australian government. It was possible still a year from getting to the market. 

In New South Wales 7,500 people got vaccinated in one day.

WIth 7 new cases of blood clots in Australia there were now 18 cases of blood clots from 1,800,000 vaccinations in Australia. That was 1 in a 100,000 chance of having it happening to you someone vaccinated. Remember 1 in 600 Americans had died from COVID last year.

An independent panel for the handling of the pandemic released its findings.
It didn’t get much news coverage despite holding many lessons for I learn from not just for future pandemics for the current ongoing one.

Some critical points were the sharing of information between nations, empowering the World Health Organisation and effectively in terms of the outbreak in the West a lack of action throughout the month of February, 2020.

ABC News reported some suggestions were a disease surveillance system that could publish information about developments in a country they were working in without the need to get permission to do so and rich countries doing more to vaccinate poorer nations.

Let’s hope some lessons are learned from the panel’s findings.

On the 12th of May, 2021 the World Health Organisation recorded in India there had been 4,205 deaths in one day.

A new record.

May 14

A new step in the vaccine roll-out a week on from the 2A cohort was due to start next Monday with 400,000 Pfizer doses to be dispensed to 14 different sites across Victoria for a small group of those under age 50.

You had to make a booking and priority would be given to critical and high risk workers, adults with underlying health conditions, disabiltiy and aged care carers and workers.

Uber Drivers and public transport workers could make a booking from May 24th the following Monday.

Victorian Acting Premier James Merlino advised the state was averaging 8,000 vaccinations a day. A testing clinic at the Melbourne Showgrounds would also open a mass vaccination hub on Monday as well.

I am very supportive of any measures to get as many people vaccinated as possible as quickly as possible. Winter is coming,” Shadow Health Minister Georgie Crozier said.

The bulk of contract tracing and COVID tests following in the wake of a man who had tested positive earlier in the week having travelled from Adelaide had returned negative results with no new daily community cases. The man had originally departed India on the 19th of April and travelled via the Maldives and Singapore.

Channel Nine News reported three hundred thousand vaccine doses had been given out so far in the state.

Army drafted in as 'mass' coronavirus testing is rolled out in Bolton | The  Bolton News

In Great Britain, Prime Minister Boris Johnson warned the staged steps to lower restrictions could be disrupted by the Indian strain which was spreading through Great Britain.

In one week Public Health England reproted cases of the variant had tripled in the country with 1,255 in England, 35 in Scotland, 12 in Northern Ireland and eleven in Wales.

On May 14th, 2021 the World Health Organisation reported in the United Kingdom there were 2,656 new daily cases.

On Monday England was due to open up pubs and restaurants and six people from two households could gather at one of their places.

After that was the fourth and final step due June 21 where there will be no limits on social gatherings indoors or outdoors, no limits on weddings and nightclubs will re-open.

That seemed to still be on the cards but the PM warned, “I have to level with you that this new variant could pose a serious disruption to our progress and could make it more difficult to move to step four in June.

But I urge everyone to exercise the greatest caution because the choices we each make in the coming days will have a material effect on the road ahead,” he added.

Having down throught the ages with one jab currently anyone over 38 could get vaccinated. Now there was a run on to cut the 12 week gap between the first and second jab to just eight weeks for those over 50 or with underlying health conditions.

Mr Johnson added that there was “no evidence to suggest that our vaccines will be less effective in protecting people against severe illness and hospitalisation”.

The UK’s Chief Medical Adviser Professor Chris Whitty warned that if the Indian variant was more transmissible the island nation would see a significant surge.

That’s a really critical question to which we do not yet have the answer. We expect over time this variant will overtake and come to dominate in the UK in the way that the Kent variant did,” he added.

Remember how the UK strain was up to 70 per cent than the orginal COVID that across the West, well the Indian strain could be 50 per cent more transmissible than the UK strain according to the Scientific Adivsory Gorup for Emergencies (Sage).

The British Army were deployed to the towns Blackburn and Bolton to help with handing out test kits.
Mobile testing units had been set up Bolton and opening hours and delivery of doses had been increased at that town’s vaccination centres.
A rapid response team of 100 nurses, public health advisers and environmental health officers had also been sent.
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In the United States of America the Centers for Disease Control (CDC) eased indoor mask wearing guidance for vaccinated people allowing them to not wear masks in most indoor places.

The CDC guidelines showed quite clearly by vaccinating you were less at risk and could engage in more activities.

As vaccinations slowed down there was a push to encourage more of the populace to drive those vaccinated numbers just a little higher.

Governors were doing their part like in Ohio where vaccinated adults could go in the draw to win one million U.S. dollars. I’ll do it for free but God Bless America.

But New York Mayor Bill De Blasio was a man more after my own heart tucking into fast food that New Yorkers could get from Shake Shack if they got vaccinated. Free fries and a burger?! Hmmmmmm.

God Bless America!

And God bless Bill de Blasio, don’t listen to the haters Mr Mayor, you looked good tucking into that burger. I would’ve made a meal of it.

-Lloyd Marken

Bill De Blasio GIFs - Get the best GIF on GIPHY

ONE YEAR EARLIER: May 13, 2020

The number of unemployed was cited as 10% or 1.4million Australians. This was the highest unemployment rate since the early 1990s recession in Australia and in which unemployment had risen at a far slower rate then during the pandemic.

May 14, 2020

A MacDonalds at Fawkner in Melbourne Victoria had 90 staff tested and isolated pending results after a break-out of eight COVID-19 cases from the fast food outlet including four staff members and four family members of a worker.

COVID-19 DIARY – ROLL OUT ROLL UP – PART VIII

April 10

Vaccinations were rolling out across regional communities in Queensland including up in the far north where we were bordered with Papua New Guinea.

April 11

Sunday.

On the 11th of April, 2021 the World Health Organisation reported there had been 135,097,616 confirmed cases globally with a daily increase of 754692.

There had been 2,921,503 deaths worldwide with a daily increase of 11,974.

In Papua New Guinea there had been 8,442 confirmed cases with a daily increase of 100. There had been 68 deaths.

In Australia there had been 29,396 confirmed cases with a daily increase of six. There had been 909 deaths.

In Canada there had been 1,045,278 confirmed cases with a daily increase of 9,255. Two days later the country would set a new record of daily new cases with 9,936. There had been 23,251 deaths with a daily increase of 40.

May 4, 2020 still remained the date where the highest number of deaths had been reported with 235.

During the second wave 210 deaths had been reported on January 9th, 2021. The highest number of daily deaths in that wave.

In the United Kingdom there had been 4,368,049 with a daily increase of 845. There had been 127,080 with a daily increase of 40.

In India there had been 13,358,805 confirmed cases with a daily increase of 152,879. There had been 169,275 deaths with a daily increase of 839.

The highest number of new daily cases during the first wave in India had been 97,894 on the 17th of September, 2020. The numbers were well beyond that now.

That record got broken on the 5th of April, 2021 with 103,558 new daily cases.

April 7th a new record again with 115,736 new cases.

April 8th – 126,789.

April 9th – 131,968.

April 10th – 145,384.

And a new record again on the 11th of April with 152,879 with no end in sight.

In Brazil there had been 13,373,174 confirmed cases with a daily increase of 93,317. There had been 348,718 deaths with a daily increase of 3,693. The day had seen their highest recorded amount of daily deaths with 4,249.

Poop tests stop COVID-19 outbreak at University of Arizona | Science | AAAS

In the United States of America there had been 30,772,857 confirmed cases with a daily increase of 80,631. Way too high as it appeared America was rising slightly in daily average of new cases. There had been 555,712 deaths with a daily increase of 929.

April 13

A report on the Channel 10 program The Project covered that the Australian government was not intending to purchase the Johnson and Johnson vaccine as it was same type of vaccine as the AztraZeneca vaccine which we were manufacturing in Melbourne at CSL Limited.

We remained reliant on delivery of the PfizerBioNTech vaccine for the majority of those under 50s going forward and had used it for the bulk of our frontline workers in healthcare and hospitality already.

So why weren’t were we manufacturing Pfizer here?

Well that was because the PfizerBioNTech vaccine was an MRNA vaccine that we didn’t have the current capability to build.

However The Project report argued with proper funding we could have such a capacity maybe in 12 months.

A year seems a long time away and facility building always seem to suffer delays but such an investment could pay off down the line in the future.

Given what had transpired in the past year and the need to give ourselves more options in the fight to overcome COVID it seemed like a compelling idea worth a further look.

April 14

In the United States of America the government hit pause in the use of new Johnson & Johnson vaccine.

“This announcement will not have a significant impact on our vaccination plan: Johnson & Johnson vaccine makes up less than 5 per cent of the recorded shots in arms in the United States to date,” Mr White House COVID-19 Response Coordinator Jeff Zients said.

As of April 12th there had been 6.8 million shots of the jab administered in the country.

Less than 5 per cent of all vaccinations in the country with Pfizer and Moderna accounting 180 million doses delivered.

Out of the 6.8million Johnson & Johnson shots there had been 6 cases of blood clots and so far no deaths.

The six cases involved all women aged 18 to 48 and symptoms occurred six to 13 days after they received their shot.

The Australian government had made a decision earlier in the week to not place orders for the vaccine. Having 170 million AstraZeneca, Pfizer and Novavax vials in the pipeline.

Johnson & Johnson COVID-19 vaccine: Here's what to know - ABC News

This is a really rare event, there have been six out of the 6.58 millions doses, this is less than one in a million, so this (pause) is out of an abundance of caution.,” advised Dr Fauci.

People are asking me if they should cancel their Johnson & Johnson vaccine appointments and I have told them not to but I know many will and this will stall progress in controlling the pandemic,” Dr. Amesh Adalja, an infectious disease expert at St John Hopkins said.

Johnson & Johnson announced it would also delay its rollout of the vaccine in Europe.

The British/Swiss Oxford AstraZeneca, the American Johnson & Johnson, the Chinese CanSino Biological and the Russsian Sputnik V vaccine were all adenovirus vector vaccine. A “cold” virus that instructs our cells to produce a spike protein found on the surface of the virus.

When your body begins producing the harmless spike protein, your immune system reacts and learns how to fight the real thing.

The Moderna and Pfizer/BioNTech vaccines use mRNA technology. Those are harder to manufacture and have to be kept in freezing temperatures as opposed to simple refrigeration.

Twenty million of the Johnson & Johnson doses had been delivered to America, they had just started getting the first of what was planned to be 75 million doses by the end of June and 120 million by end of September.

Three hundred thousand vaccinations had been given in South Africa.

Four hundred million doses were scheduled to go to the Africa bloc.

Remember how I said this would be the vaccine given to the third world because it was a one shot jab that doesn’t require refrigeration?

GSK to manufacture 60 million doses of Novavax vaccine for the UK

As America hit pause on Johnson & Johnson and Australia demurred the vaccine, the spotlight turned to Novavax a little in my country.

With Pfizer as the preferred vaccine for under 50s, the bulk of which was scheduled to come in the final quarter of 2021 – Australia’s third vaccine became of greater importance.

Fifty one million doses to come sometime in mid-2021 but when could be anywhere from July to September now following supply shortages.

“When you start producing [vaccines] at a scale of millions and millions and millions, I mean, small scale is fine, but whenever manufacturing is required at that scale, there will always be a challenge. Whether that be the packaging or the supply chain.” QIMR Berghofer Medical Research Institute’s Professor Rajiv Khanna said.

The American produced Novavax worked in a similar way to the adenovirus vaccines but used the same spike protein as the virus.

The protein is then collected, concentrated, purified and mixed with other chemicals to make sure the body’s immune system mounts a strong response.

Trials in Great Britain with 15,000 people resulted in an efficacy rate of 89.3 per cent.
Pfizer had a efficacy rate of 95%, Moderna at 94.1%, the efficacy of AstraZeneca had a wider range of results from 62 to 90 per cent. A recent study published in The Lancet showed a twelve week wait between doses which was becoming the norm in places like the UK and Australia showed 82 per cent.
Trials in South Africa up against the South African variant had the rate go down to as low as 49.4 per cent.
While we weren’t taking up Johnson & Johnson for the moment and Novavax was our third and currently last option, the vaccine was likely to be approved for other countries (many invested in its development) before Australia.

Coronavirus: Qantas further cuts international flights, grounds eight A380s  – Business Traveller

April 15

Prime Minister Scott Morrison was working on a scheme people returning from trips overseas quarantining at home. If they had been vaccinated. This would be for initial essential overseas travel like business deals, medical procedures and family funerals.

Vaccinations had also taken a dip following the government’s announcement last Thursday night.

The Prime Minister also announced an intention to have the 16 million Australians under 50 receive their first and second Pfizer doses through October to December 2021 using mass vaccination sites but who would man them was raised in response.

That would require 230,000 vaccinations a day.

-Lloyd Marken

ONE YEAR EARLIER: April 11, 2020

The United States of America overtakes Italy as the country with the highest number of deaths due to COVID-19.

April 12, 2020

Prime Minister Boris Johnson is released from hospital having survived COVID-19 thanks to the dedicated NHS staff who saw him through intensive care.

April 13, 2020 

CBS Reporter Paula Reid took it to Ballbag in a press conference after he had consistently behaved in an appalling manner for several week offering no correct and consistent messaging and seemed more invested in belittling reporters rather than answering really simple questions. This time he couldn’t even manage that. 

April 15, 2020

Term 2 started for schools around Australia with most states opting for remote learning where students were not children of essential workers.

In Potters Field on Hart Island in the Bronx. They buried the dead.